Alpha lipoic acid (ALA), also known as Lipoic acid (LA), α-lipoic acid and thioctic acid is an organosulfur compound derived from octanoic acid. ALA is made in animals normally, and is essential for aerobic metabolism. It is also manufactured and is available as a dietary supplement in some countries where it is marketed as an antioxidant, and is available as a pharmaceutical drug in other countries.
Lipoic acid is divided into alpha lipoic acid and dextral lipoic acid, which can be used as a coenzyme to participate in the acyl transfer of substance metabolism in the body, and can eliminate free radicals leading to accelerated aging and disease. Lipoic acid is both lipid-soluble and water-soluble. Lipoic acid is mainly used as auxiliary material in the field of hypoglycemia.
Alpha-lipoic acid is an antioxidant that is made naturally in the body and also found in foods. It is used to break down carbohydrates and to make energy.
Alpha-lipoic acid can be eaten in foods, such as red meat, carrots, beets, spinach, broccoli, and potatoes. It is also available in supplements. Because alpha-lipoic acid seems to work like an antioxidant, it might provide protection to the brain and also be helpful in certain liver diseases.
| ITEM | SPECIFICATION | RESULT | METHOD |
| Assay | 99.9%-101.0% | 99.20% | HPLC |
| Appearance | Slight yellow crystal Powder | Complies | Organoleptie |
| Identification | Meets the requirements | Complies | HPLC |
| Specific rotation | （-1.0° to + 1.0° ） | 0° | USP |
| Melting Piont | 60.0-62.0℃ | 60.5-61.8℃ | USP |
| Loss on Drying | 0.20 max | 0.07% | USP |
| Ash | 0.1max | 0.04% | USP |
| Residue on Ignition | 0.1% max | 0.04% | USP |
| Heavy metals | ＜10ppm | Complies | USP |
| Pb | ≤3.0ppm | ＜3.0ppm | USP |
| As | ≤1.0ppm | ＜1.0ppm | USP |
| Hg | ≤0.1ppm | ＜0.1ppm | USP |
| Cd | ≤1ppm | ＜1ppm | USP |
| Chromatographic purity | |||
| Polymeric lipoic aicd | ≤1 | Complies | Complies |
| Cyelohexane | 3880 ppm max | 0.27% | GC |
| Ethyl Aeetate | 500 ppm max | Not detectable | GC |
| Toluene | 20 ppm max | Not detectable | GC |
| Total microbacterial count | ≤1,000cfu/g | <10 cfu/g | USP |
| Total Yeast & Mold | ≤100cfu/g | <10 cfu/g | USP |
| E.coli Salmonella | Absence /g | Not detectable | USP |
| Staphylocoeeus aureus | Absence /g | Not detectable | USP |
| Partical size | 100% through 40 mesh | Conforms | USP |
| Conclusion : | Conformed USP 43 | ||
Application
Medical field: it can prevent the combination of sugar and protein, has the effect of anti-glycosylation, used in the field of liver disease and diabetes; Can eliminate fatigue; Lipoic acid has antioxidant properties that may improve dementia; Lipoic acid as an antioxidant function, can inhibit cancer, help allergies, arthritis and asthma; Lipoic acid helps treat cardiovascular and cerebrovascular diseases and kidney diseases.
Cosmetics: can remove free radicals, has good water solubility and fat solubility, with coenzyme Q10 can be used as anti-oxidation and anti-aging skin care products; Can reduce the damage of ultraviolet ray to skin.
